Instrumentation
The BIO Center operates across seven laboratories in two buildings on campus, McCollum Laboratories and the Higuchi Laboratories animal facility.
Characterization of Lead Compounds
- Solubility and stability screening
- Protein binding
- Plasma stability
- Hepatic microsomal stability
- Rodent (mouse and rat) pharmacokinetic
- Tissue distribution studies
- pH-degradation rate profiling
- Accelerated stability testing
- Particle size analysis
- Prodrug development
- Crystal form evaluations
- Evaluation of solubility enhancers
Formulation and Analytical Chemistry
- Oral dosage forms: solutions, suspensions, emulsions
- Oral reconstituted powders
- Parenteral dosage forms
- Injectable solutions
- Lyophilized powders
- Injectable nanoparticle suspensions
- Immediate, chewable, extended and controlled delivery
- Modified release; matrix and coated tablets
- Direct compression, wet granulation instrumented tablet press
- Multi-particulate dosage forms
- Extrusion / spherionization
- Immediate release, extended and controlled release
- USP dissolution/disintegration testing
- Assay development and validation
- Bioanalytical methods
- HPLC, GC,LC/MS/MS instrumentation
- Stability testing
In Vivo Evaluations
- Small animal pharmacokinetics and pharmacodynamics
- PK/PD modeling
- Bioavailability studies
- Tissue distribution studies
- Prodrug conversion studies
- Maximum tolerated dose studies
- Metabolism studies