Instrumentation

The BIO Center operates across seven laboratories in two buildings on campus, McCollum Laboratories and the Higuchi Laboratories animal facility.

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Physical & Chemical Characterization

  • Protein binding (mouse, rat, dog, human)
  • Hepatic microsomal & plasma stability
  • Permeability assessment
    • LogP & LogD (computational & measured)
    • Side-by-side membrane diffusion cells
    • Caco-2 (by contract)
  • Solubility (pH, temperature, solubilizers)
  • Stability (pH, temperature, light, oxidative stress)
  • Super saturation & amorphous solubility
  • Ionization constant (pKa)
  • Particle size analysis
  • Prodrug characterization & stability
  • Solid form identification & characterization
  • Surface tension & viscosity measurements
  • Osmotic pressure measurements
  • Moisture content measurement & analysis 
  • Dissolution (intrinsic, compendial)
  • Computational predictions & molecular simulation
  • Biological characterization (peptide & proteins)

Formulation and Analytical Method Development

  • Oral dosage forms: solutions, suspensions & emulsions
  • Oral reconstituted powders
  • Parenteral dosage forms
    • Injectable solutions
    • Lyophilized powders
    • Nanoparticulate colloids
  • Tablets
    • Immediate release
    • Extended release
    • Chewable
  • Dry powder and liquid-filled capsules
  • Modified release tablets; matrix & coated
  • Direct compression, wet/dry granulation
  • Multi-particulate dosage forms
    • Extrusion/spheronization
    • Immediate release, extended & controlled release
    • Fluid bed coating
  • Spray dried & amorphous solid dispersion
  • Assay development & implementation for:
    • Drug substances/products
    • Complex biological samples
      • In-vitro cell containing media
      • Plasma, urine, tissues/organs, tumors 
  • Utilize UPLC/HPLC (UV, Fluorescence, ELSD, QDa, LCMSMS, GC)
  • Dissolution & drug release (USP paddle, rotating disc)
  • Subcutaneous drug release (ESCAR)

In-Vivo Evaluations

  • Pharmacokinetic analysis & modeling (full & abbreviated)
  • Maximum tolerated dose (MTD)
  • Tissue distribution (plasma, urine, organs, tumors)
  • Bioavailability (PO, SC, IV, IP, topical, inhalation)
  • Prodrug conversion & elimination 

Processing & Analytical Equipment

  • Fluid bed coater
  • RETSCH mill
  • Turbula shaker/mixer
  • Stokes tablet press
  • NicaSystem AB extruder
  • Luwa Model maurumerizer
  • Vitris Genesis tray and shelf lyophilizers
  • Fluid Nozzle Spray Dryer (4M8-TriX by ProCepT)
  • Avestin Emulsiflex B3 & C3 homogenizers
  • 197 Underdriven Comil
  • Stability chambers
  • Waters XevoTQS & XevoTQS-micro UPLC/MS/MS system
  • Waters Acquity UPLC with PDA & QDa mass detector 
  • Shimadzu HPLC with PDA, ELSD, & fluorescence
  • Atlas Suntest
  • mDSC, TGA & DVS
  • Karl Fischer Titration Coulmeter
  • Jasco J-1500 CD
  • DLS Malvern Zetasizer
  • Malvern 3000 Particle Size Analyzer 
  • Tensiometer KRUSS-100
  • m-VROC 2
  • Beckman Optima Max-XP Ultracentrifuge
  • Gastrointestinal simulator 
  • Distek Dissolution system 2500
  • Distek Eclipse 5300
  • Shimadzu GC-2010

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