Instrumentation
The BIO Center operates across seven laboratories in two buildings on campus, McCollum Laboratories and the Higuchi Laboratories animal facility.
Physical & Chemical Characterization
- Protein binding (mouse, rat, dog, human)
- Hepatic microsomal & plasma stability
- Permeability assessment
- LogP & LogD (computational & measured)
- Side-by-side membrane diffusion cells
- Caco-2 (by contract)
- Solubility (pH, temperature, solubilizers)
- Stability (pH, temperature, light, oxidative stress)
- Super saturation & amorphous solubility
- Ionization constant (pKa)
- Particle size analysis
- Prodrug characterization & stability
- Solid form identification & characterization
- Surface tension & viscosity measurements
- Osmotic pressure measurements
- Moisture content measurement & analysis
- Dissolution (intrinsic, compendial)
- Computational predictions & molecular simulation
- Biological characterization (peptide & proteins)
Formulation and Analytical Method Development
- Oral dosage forms: solutions, suspensions & emulsions
- Oral reconstituted powders
- Parenteral dosage forms
- Injectable solutions
- Lyophilized powders
- Nanoparticulate colloids
- Tablets
- Immediate release
- Extended release
- Chewable
- Dry powder and liquid-filled capsules
- Modified release tablets; matrix & coated
- Direct compression, wet/dry granulation
- Multi-particulate dosage forms
- Extrusion/spheronization
- Immediate release, extended & controlled release
- Fluid bed coating
- Spray dried & amorphous solid dispersion
- Assay development & implementation for:
- Drug substances/products
- Complex biological samples
- In-vitro cell containing media
- Plasma, urine, tissues/organs, tumors
- Utilize UPLC/HPLC (UV, Fluorescence, ELSD, QDa, LCMSMS, GC)
- Dissolution & drug release (USP paddle, rotating disc)
- Subcutaneous drug release (ESCAR)
In-Vivo Evaluations
- Pharmacokinetic analysis & modeling (full & abbreviated)
- Maximum tolerated dose (MTD)
- Tissue distribution (plasma, urine, organs, tumors)
- Bioavailability (PO, SC, IV, IP, topical, inhalation)
- Prodrug conversion & elimination
Processing & Analytical Equipment
- Fluid bed coater
- RETSCH mill
- Turbula shaker/mixer
- Stokes tablet press
- NicaSystem AB extruder
- Luwa Model maurumerizer
- Vitris Genesis tray and shelf lyophilizers
- Fluid Nozzle Spray Dryer (4M8-TriX by ProCepT)
- Avestin Emulsiflex B3 & C3 homogenizers
- 197 Underdriven Comil
- Stability chambers
- Waters XevoTQS & XevoTQS-micro UPLC/MS/MS system
- Waters Acquity UPLC with PDA & QDa mass detector
- Shimadzu HPLC with PDA, ELSD, & fluorescence
- Atlas Suntest
- mDSC, TGA & DVS
- Karl Fischer Titration Coulmeter
- Distek USP Dissolution system
- Jasco J-1500 CD
- DLS Malvern Zetasizer
- Malvern 3000 Particle Size Analyzer
- Tensiometer KRUSS-100
- m-VROC 2
- Beckman Optima Max-XP Ultracentrifuge
- Gastrointestinal simulator