Research Resource Core Laboratory

Capabilities and Instrumentation

Characterization of Lead Compounds

  • Solubility and stability screening
  • Protein binding
  • Plasma stability
  • Hepatic microsomal stability
  • Rodent (mouse and rat) pharmacokinetic
  • Tissue distribution studies
  • pH-degradation rate profiling
  • Accelerated stability testing
  • Particle size analysis
  • Prodrug development
  • Crystal form evaluations
  • Evaluation of solubility enhancers

Formulation and Analytical Chemistry

  • Oral dosage forms: solutions, suspensions, emulsions
  • Oral reconstituted powders
  • Parenteral dosage forms
  • Injectable solutions
  • Lyophilized powders
  • Injectable nanoparticle suspensions
Tablets and Solids
  • Immediate, chewable, extended and controlled delivery
  • Modified release; matrix and coated tablets
  • Direct compression, wet granulation instrumented tablet press
  • Multi-particulate dosage forms
  • Extrusion / spherionization
  • Immediate release, extended and controlled release
  • USP dissolution/disintegration testing
Analytical Chemistry
  • Assay development and validation
  • Bioanalytical methods
  • HPLC, GC,LC/MS/MS instrumentation
  • Stability testing

In Vivo Evaluations

Studies and Techniques
  • Small animal pharmacokinetics and pharmacodynamics
  • PK/PD modeling
  • Bioavailability studies
  • Tissue distribution studies
  • Prodrug conversion studies
  • Maximum tolerated dose studies
  • Metabolism studies

Contact the BIO Center

Michael J. Hageman, PhD

Lanaea Heine

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